Objective: To explore the DRG case combination and hospitalization expense standard of children aged 0~6 years old who fell, and to provide references for scientific analysis of hospitalization expenses and formulation of targeted cost control measures. Methods: A total of 2 773 children aged 0~6 who were hospitalized due to falls in the homepage database of inpatient medical records from 2010 to 2021 in 2 class A tertiary hospitals and 6 class A secondary hospitals in Xinjiang were selected, and multiple linear regression model, quantile regression model and decision tree model were used for case combination analysis. Results: The total hospitalization expenses of children who fell were 24 571 782.09 yuan, and the average hospitalization expenses were 5 543.36 yuan. Taking the length of stay as the influencing variable, and the main influencing factors (P＜0.05) such as hospital grade, residential area, admission status, injury nature, injury site, operation grade, whether to change majors, complications and payment method as the classification nodes, 15 DRG case combinations were constructed, and the corresponding hospitalization expenses standards and disease weights were formulated. There were 340 cases with hospitalization expenses exceeding the standard. Conclusion: It is reasonable to construct the DRG case combination of children with falls by fractional regression and decision tree model, which is beneficial to control the hospitalization expenses, reduce the financial burden of children’s families, and provide a basis for the reform of medical expenses payment methods.