Objective: In view of the problems of insufficient vitality of the disease prevention and control talent team, the estab- lishment of a salary-factor based salary determination mechanism of the disease prevention and control institution was studied. Meth- ods: Comprehensive use of expert analytic hierarchy and other methods, following the framework of salary determination mechanism, human capital theory, compensatory wages and other theories. Results: From the perspectives of disease prevention and control insti- tutions work characteristics and personnel characteristics, 7 salary elements and 15 indicators of the disease prevention and control institutions were extracted, and the weights of each element and indicators were determined. The salary level of the disease preven- tion and control institutions should be increased by 0.38 times from the current level, and the salary structure should account for 51% of the guaranteed part and 49% of the change part. Conclusion: Construct a salary determination mechanism based on salary el- ements, optimize salary structure, and promote the reform of disease prevention and control institution salary incentive system.