Objective: To explore the spatiotemporal evolution characteristics and driving factors of the degree of coupling and co- ordination between the allocation of medical resources and economic development in the six provinces in central China, so as to pro- vide rational suggestions for promoting the synergistic and orderly development of health care and regional economy in 6 central provinces. Methods: Exploring the spatial-temporal evolution of the coupling and coordinated development of healthcare resource alloca- tion and economy in 6 central provinces and its driving factors by combining the coupled coordination degree model and fixed effects model. Results: The overall level of coupling and coordination between medical resource allocation and economic development in 6 central provinces from 2010 to 2020 shows a steady upward trend, but the overall level is low, with significant regional disparities. The level of economic development, industrial structure, government investment and investment in science and technology all have a positive effect on the coordinated development of medical resource allocation and economy in 6 central provinces. The level of economic development has the greatest effect, followed by the industrial structure and the least by the investment in science and technology. Conclusion: For six central provinces, it is needed to accelerate the transformation and upgrading of their industrial structure, im- prove their economic development, increase financial support, implement differentiated fiscal policies, continuously optimize the alloca- tion of medical resources and promote the coordinated development of regional medical resource allocation and economic coupling