During the "14th Five-Year Plan" period，the national level focused on carrying out the "Four Key Projects"，and promoting the construction of regional medical centers was one of them. In the process of construction，there are several outstanding problems in financial management. It is recommended to implement the responsibility of the main body of operation and the decision-making power of business management，strengthen the construction of financial talents，build a bench marking financial management system，innovate the financial accounting subject system，and build a performance evaluation index system. Explore the optimal path in six aspects，including building a financial sharing information platform，so as to give full play to the synergy and sharing effects of financial regions，and ultimately contribute to the sustainable development of regional medical centers.