Objective: To compare the effects of different drug procurement policies on drug price decline in Anhui Province. Methods: The drug procurement data of Anhui Medical Insurance Bureau in the past five years were used to compare the provincial drug price index under different procurement policies and the contribution rate of different procurement policies to the price index based on chain pull price index mode. Results: The price of centralized procurement of drugs in Anhui Province from 2018 to 2022 was dynamically analyzed and predicted，and the data sample of drug procurement index in Anhui Province was fixed，which was used as the sample of normalized index calculation in the following five years. After the establishment of the Medical Insurance Bureau，the price index of the centralized drug procurement policy with quantity has decreased significantly compared with the traditional centralized drug procurement policy by bidding，and the impact of different policies on price decline are as follows: national centralized procurement，centralized procurement expansion variety gradient price reduction，provincial centralized procurement，national medical insurance catalogue negotiation and provincial key drug monitoring policy. The main influencing factors are the committed procurement volume and the scope of negotiation catalogue. Conclusion: The policy of purchasing drugs with quantity is helpful to control the drug cost and save the medical insurance funds. It is necessary to expand the committed purchasing quantity and increase the scope of centralized purchasing drug catalogue by means of provincial and municipal alliances，especially to expand the scope and regional coverage of centralized purchasing of Chinese patent medicines and biological products.