Objective: To analyze the impact of the application and promotion of new technology on the payment of surgical patients' Diagnosis Related Group (DRG) in a special hospital so as to provide scientific basis for the formulation of reasonable DRG payment policy. Methods: The hospital medical record data of Shanghai medical insurance payment reform information service platform in 2021 were selected and included into the new technology (diagnosis and treatment items) carried out in the past two years and filed by the superior department. Independent sample T-test，Chi-square test and rank sum test were used to analyze the influence of the use of new technology on the cost，length of stay and quality index of major breast surgery (EB19) in hospitals. Results: The application of new technology increased the number of days in hospital and medical expenses of patients，and had an impact on the itemized costs of medical expenses，even causing losses to the hospital. However，in terms of medical quality，the performance of patients who used new medical technology was better than those who do not use it. Conclusion: Under the DRG payment，in order to promote the development of new technology and promote the high-quality development of hospitals，it is necessary to formulate a reasonable payment policy for new technology to avoid the cost loss of medical institutions. Meanwhile，medical institutions need to strengthen medical technical supervision to ensure medical quality and safety.