Based on the six systems (medical service system，talent cultivation system，science and technology innovation system，fine management system，open and cooperative system，party building culture system) of high-quality development of public hospitals，it analyzes the core problems faced by high-quality development of public hospitals from optimizing the layout of disciplines，balancing scientific research and clinical practice，strengthening team building，innovating development mode，actively opening up cooperation and keeping positive innovation culture. On this basis，taking Peking Union Medical College Hospital as an example，the strategic objectives，existing problems and future development direction and recommendations of Peking Union Medical College Hospital were discussed under the six systems to achieve high-quality development of public hospitals. In order to deal with these relationships and solve these core problems，discipline differentiation and integration，hospital integration，collaboration and openness，hospital information and intelligence in management and services are discussed in the process of dealing with hospital rankings and evaluation criteria，clinical services and teaching and scientific research，service capabilities and bed size，hospital organizational structure changes，so as to point out the direction for the high-quality development of public hospitals.