Objective: To analyze the effects of national drug centralized procurement policy to research the market change of lipid-regulating drugs before and after the implementation of this policy. Methods: Based on the lipid-regulating drugs sales data from 2015 to 2021 in sample hospitals from Pharmaceutical Database of China National Pharmaceutical Industry Information Center，it makes comparative analysis on the effect of sales of lipid-regulating drugs，the percentage of sales volume and sales of medicine that belong to or not belong to national drug centralized procurement. Besides，the percentage of sales volume and sales of the original drug，generic medicine passing consistency evaluation and generic medicine failing consistency evaluation are also analyzed. Results: After implementation of national drug centralized procurement policy，the sales of lipid-regulating drugs decreased. The different medicines of national drug centralized procurement had different phenomenon in sales volume and sales. The sales of original drug that belong to the national drug centralized procurement increased，while the sales volume decreased. Conclusion: The policy has significant effect in saving drug cost，while there are still problems such as the patent cliff still hasn't appeared，and the sales of alternative medicines have raised. It suggests that implementation of national drug centralized procurement policy should reasonably select collection varieties，while strengthening the monitoring of alternative medicines and generic medicine failing consistency evaluation.