Objective: To investigate the relationship between Health-Related Quality of life (HRQol) and the outpatient and inpatient utilization in patients with cardiovascular disease (CVD). Methods: Patients with coronary heart disease and stroke from the special survey on social factors of prevention and control of chronic diseases in Suqian City in 2019 were selected as the objects. The EQ-5D-3L scale was used to evaluate the HRQol, and the utilization of outpatient services and inpatient services in the past year were used to measure the health services utilization. Logistic regression was used to analyze the effect of HRQol on health service utilization in patients with CVD. Results: A total of 1774 patients with CVD were included, including 844 patients with coronary heart disease and 1135 patients with stroke. The co-occurrence rate of these two diseases was 11.56 %. During the survey period, the outpatient service utilization rate of CVD patients was 49.4 %, and the inpatient services utilization rate was 30.9 %. The overall health utility value was (0.912 ±0.133), and the EQ-VAS score was (68.93 ±13.01). Logistic regression results showed that the likelihood of outpatient service utilization and inpatient service utilization of patients would be decreased by 74.4 %and 61.4 %, respectively, when the health utility value increased by 1 unit. The likelihood of outpatient service utilization and inpatient service utilization of patients would be decreased by 3.1 %and 2.8 %, respectively, when the EQ-VAS increased by 1 unit. In addition, the results showed that patients with farmer and hypertension were more likely to use outpatient services (P＜0.05); patients with male, farmer, low education level, no medical insurance, no alcohol, diabetes, and concomitant coronary heart disease and stroke were more likely to use inpatient services (P＜0.05). Conclusion: HRQol is the important factor for health service utilization. Targeted measures should be taken to improve the HRQol of patients, strengthen the capacity building of primary medical and health service institutions, promote the optimization of medical and health service utilization, so as to better meet the health needs of CVD patients.