Informationization construction projects have large differences in cost measurement due to different needs，development environments and languages. The state has not yet established a unified budget quota standard system for them. There is a lack of evaluation scales for auditing them，so auditing institutions generally rarely touch on informationization construction project audits. There is a lack of audit coverage. It focus on how to effectively implement the requirements of the Party Central Committee and the State Council on the implementation of full audit coverage of public funds，and combined with the background of the vigorous development of hospital informatization construction，it investigates the audit strategy of hospital informatization construction projects，elaborates on the methods and contents of hospital informatization project audits，the main points，and proposes that the new situation of informatization project audit methods should keep pace with the development of informatization.