Objective: To provide policy recommendations for optimizing the efficiency and spatial distribution of China's healthcare resources and achieving a balance between supply and demand in the allocation of healthcare resources. Methods: Based on the medical resource supply capacity index and demand pressure index of 31 provinces and cities in China in 2020，the coupling coordination degree model of medical resource supply and demand in China is established by introducing the coupling theory of physics，and the spatial difference of the coupling coordination of medical resource supply and demand in China is discussed with the help of spatial econometrics. Results: The coupling degree of medical resource supply and demand in China is above 0.83. Coupling coordination degree shows that the proportion of moderately coordinated regions is 22.60 %，the proportion of barely coordinated areas is 54.80 %，and the proportion of maladjusted areas is 22.60 %. The proportion of regions with balanced development of medical resources in China is only 9.70 %，while the proportion of regions with unbalanced medical resources is as high as 90.30 %. Conclusion: The supply and demand of medical resources in China are in a high coupling stage. However，the overall coordination level of medical resources supplies and demand is not high and the imbalance between supply and demand is obvious，with significant differences in different areas，showing a gradual decline from the eastern regions to the central and western regions.