To construct a scientific and objective "friendly" inclusive health insurance evaluation index system for rare diseases, and to provide a reference basis for inclusive health insurance to better participate in the multi-level guarantee of rare diseases. On the basis of literature research, principal component analysis (PCA) is used to determine the evaluation system and index weight, and the index measurement and application of 62 inclusive health insurance in China that are not limited to rare diseases, genotype diseases or genetic diseases are also carried out. On the basis of ensuring the stable and continuous operation of the fund, reasonable pre-existing condition clauses and liability exemption clauses are set for the products. It explores the establishment of a general insurance list of special drugs or local special security system. On the basis of the insurance of out-of-catalogue hospitalization, the responsibility of outpatient service should be increased.