Objective: To provide a basis for the rational allocation of health resources in Xinjiang, this study evaluate the population and spatial regional equity of the health resource allocation in Xinjiang area. Methods: Gini coefficient was used to evaluate the population equity of the health resource allocation. Global and Local Moran’s I methods were used to explore the spatial equity of the health resource allocation in Xinjiang area. Results: The Gini coefficients during 2010-2015 ranged from 0.484 to 0.711, and there is a decline trend in overall Gini coefficient. Global spatial autocorrelation analysis of the the health resource allocation suggested that the the health resource allocation in Xinjiang had a mutual influence. Additionally, the “Low-Low” areas of the health resource allocation in Xinjiang are mainly distributed in Kashi, Aksu, and Hotan et al. The “High-High” area is mainly distributed in Changji area. Conclusion: There is an inequity in the the health resource allocation in Xinjiang. Therefore, there is a need for the related governmental department to give special policy support according to the spatial distribution differences