Objective: To explore the adjustment direction of new National Reimbursement Drug List(NDRL) and provide guidance about supplement of Reimbursement Drug List for each province. Method: Comparing the difference about NDRL between 2009 and 2017 with instruments including EXCEL and SPSS18.0 . Results: More drugs and negotiated drugs are added into the new NDRL; The classification method of western drugs has been changed; The amount of supplementary drugs is more than eliminated drugs; The main dosage of supplementary drugs form is granules and Oral Liquid; The growth proportion of Class-A and Class-B is similar; The government has imposed restrictions on drug indication and canceled limit to r eimbursement of outpatient service. Conclusion: The new NDRL supports with the hand the T raditional Chinese medicine and pays more attention to expensive drugs and p ediatric drugs. It also subdivides the drug classification and make catalog management more strictly.