Objective: The practice proves that the internal audit supervision plays an important role in the hospital economic contract management. Methods: From the strengthening of economic contract supervision and management to start, introduce Wuhu Second People’s Hospital how to use the supervision of the audit department in the contract management to ensure the normal operation of economic activities. Results: The contract management and risk awareness of the relevant departments of the hospital are strengthened, and the contract management is standardized and institutionalized. Conclusion: Through the internal audit supervision, improve the contract management system, reduce financial risk, and improve the level of financial management.