Abstract Objestive:retrospective analysis of medicine Zero spreads after the implementation of the policy of drug price compensation income increase and reduce income to abstract, the evaluation price policy compensation in place of proportion and the effectiveness of the reform, to provide a reference for the implementation of drug zero profit policy. Method : to get the 2013 to 2016 western medicine in hospital information system using the total medicine Zero spreads before and after the implementation of medical charge price list and project number, divided into outpatient and inpatient pharmacy benefits and reduce medical computing project fees increase. Results from 2013 to 2016 the price of compensation policy in place rate were 94.59%, 89.51%, 95.18%, 95.64%; 4 year total compensation policy in place rate was 93.67%; outpatient compensation mainly by inspecting fee (75.22%), the cost of treatment (11.18%), surgery (5.91%); hospital compensation mainly surgical fees, nursing fees (36.40%) (19.09%), (19.08%) medical expenses and treatment expenses (13.53%); a good compensation effect of price policy. Conclusion: the compensation of price policy is in accordance with the expectation of reform, and the sharing of information with the competent department of price can help to establish a scientific and reasonable price compensation policy.