Application of Multiple Criteria Decision Analysis in Prophylactic Therapy on Hemophilia A in ChinaShanlian Hu. 1,2 , Jiangjiang He 2, Yan Yang2, Qi Kang21.School of Public Health, Fudan University, ShangHai 200032. 2. Department of Health Policy Research, Shanghai Medical Information Center（Shanghai Health Development Research Center）, ShangHai 200040. OBJECTIIVES: To compare the main therapeutic factors of hemophilia A treatment, evaluate the advantages and disadvantages of different treatment programs, and then provide a reference for the decision of the treatment program.Using MDCA approach to evaluate the main attributes impact on the clinical efficacy and analyzes the strengths and weakness between FVIII treatment on-demand and prophylaxis in order to make consensus building in Chinese clinical key opinion leaders. METHODS: Using MDCA approach to evaluate the main attributes impact on the clinical efficacy and analyzes the strengths and weakness between FVIII treatment on-demand and prophylaxis in order to make consensus building in Chinese clinical key opinion leaders. The number of scores in each attribute is at the range from 1 to 10, 1 is the most important, 10 Divided into the most important; and access to different characteristics of the weight of indicators. RESULTS: The important attributes are reducing the number of bleedings, disability rate, and days of absenteeism from work/school, improve quality of life, return back to normal life. The total scores in treatment on-demand is the lowest one (160.54), low-dose prophylactic therapy is in the middle (234.76), the highest score is standard prophylactic therapy (263.84). In the treatment program, reduce the total number of bleeding (including joint bleeding), reduce morbidity, improve the quality of life of patients, patients can normal life and study of these aspects, clinical experts generally believe that the standard preventive treatment program the best; Analysis found that the standard dose of prevention and treatment costs are high (￥345,000 yuan), but the treatment effect is much better than the low dose of preventive treatment and on-demand treatment program. CONCLUSIONS: MCDA method can be used on clinical decision making on selecting hemophilia therapy. General speaking, the cost of lifelong prophylaxis is much less than that of treatment on-demand. However, In China, although the cost of FVIII treatment on-demand can be reimbursed by basic medical insurance system and catastrophic insurance scheme, it is inequity; the ratio of reimbursement and ceiling threshold various region by region. Prophylaxis therapy is a cost-effective regimen if it can be started in childhood stage.