As an invisible hand, the price of medical service plays an important role in regulating the supply and demand of medical service, promoting the flow and allocation of health resources and so on. Therefore, straightening out the price system of medical service has gradually become the core task of medical reform. At present, the price system of medical service is not so optimistic. It has been urgent to promote the medical service price reform. This paper analyzes the current situation of the medical service price system in Guangdong Province, combs the current price reform in public hospitals of provinces and cities, and studies on straightening out the medical service price system of Guangdong Province.